Since this seemed to be an answer that really spoke to alot of people, I thought I would share my answer here as well.
What is the difference between God and the Holy Spirit?
God is our Creator. Our Source.
Holy Spirit is the voice for God / Love that exists in our minds.
God knows not of what we do here, he knows us only as his beloved children. But he does know that we do not remember him...this is why he gave us the Holy Spirit....so we can remember Him.
HS can see our illusions but also knows us as God created us, and therefore he is the bridge to heaven...and helps us very gently to return to peace.
HS is also the corrector of our perception...the voice of reason/sanity that exists in all of us. We do not have to be Christian to have the Holy Spirit. We all have holy spirit...however... we all must choose and decide to listen to holy spirit within and not our egos.